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Plasma levels of sex hormones and IL levels did not differ by fetal sex. Systemic inflammatory priming in normal pregnancy and preeclampsia: Cytokines and angiogenic factors that exhibited significant differences according to fetal sex and gestational interval increased or decreased based on fetal sex and gestational interval were analyzed to determine their role in transcription factor networks and biological processes. Colgan J, Rothman P. Supporting Information Additional Supporting Information may be found in the online version of this article: It is unknown whether the sex of the fetus differentially alters the maternal immune milieu, potentially contributing to the observed differences. These results suggest that tolerance induction programs may be divergent based upon fetal sex, although these results do not define the mechanism by which such adaptation occurs. Each woman had samples analyzed on the same plate to minimize plate-to-plate variability.

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